The Safety of Fish Oil Supplements:

It is Complicated and In the Details

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

It is consistently recommended in many of the books, seminars, conferences, webinars and podcasts I have read and participated in to take at least 3 grams of omega 3 (EPA/DHA) fish oils in the way of supplements and food to improve cardiovascular health.

For many years this has been my recommendations for many patients.

However after review of the literature and receiving concerns among patients experiencing episodic heart palpitations, I am now questioning the necessity to make a "global" recommendation of fish oils to ALL patients.

Unfortunately the topic of fish oil recommendations is somewhat complicated but at the same time has a simple solution to ensure you are not over prescribing fish oils creating cardiovascular complications but instead helping your patients to achieve optimal cardiovascular health.

A recent peer review paper published the British Medical Journal in 2024 stated the following:

The researchers discovered that regular use of fish oil supplements could increase the risk of first-time heart disease and stroke among those with good heart health. A 13% increased risk of developing atrial fibrillation was found in there study.

They also had a 5% increased risk of stroke.

For the study, the team analyzed data from nearly 416,000 people ages 40 to 69 participating in a large-scale health study in the United Kingdom.

Nearly a third (32%) said they regularly use fish oil supplements.

The research team then tracked the health of participants for an average of nearly 12 years, watching to see how many died, developed heart problems or suffered a stroke.

During an average monitoring period of nearly these 12 years, 18,367 participants developed atrial fibrillation, 22,636 had a heart attack/stroke or developed heart failure, and 22,140 died.

Among those who progressed from good cardiovascular health to atrial fibrillation, 3085 developed heart failure, 1180 had a stroke, and 1415 a heart attack. And 2436 of those with heart failure died, as did 2088 of those who had had a stroke, and 2098 of those who had had a heart attack.

However, on the other hand the long-term study also found that fish oil can help those whose hearts are already in trouble, potentially slowing the progression of heart problems and lowering the risk of death.

But in those with existing heart disease, regular use of fish oil lowered risk of a heart attack due to atrial fibrillation by 15%, and the risk of heart failure leading to death by 9%.

Regular use of fish oil supplements might increase, rather than lessen, the risk of first time heart disease and stroke among those in good cardiovascular health, but may also slow the progression of existing poor cardiovascular health and lower the risk of death.

The researcher concluded that regular use of fish oil supplements might have different roles in the progression of cardiovascular disease,” based on whether someone already has heart problems.

Neurologist Dr. Richard Isaacson, director of research at the Institute for Neurodegenerative Diseases in Boca Raton, Florida told CNN that when it comes to fish oil, “the devil is in the details."

If you are like me you may be know scratching your head wondering if it is safe to take or simply avoid fish oils altogether.

The answer as mentioned above is quite SIMPLE.

It all comes down to testing and obtaining clear objective metrics to determine if one is truly deficient in Omega 3 fatty acids.

This can be easily done by putting in a lab order with Labcorp or Quest for the OmegaCheck Test. The Labcorp Code is: 823430 and the Quest Code is: 92701

The following are two recent patients of mine both suffering with complicated cardiovascular issues (atherosclerosis, endothelial (arterial) dysfunction, hypertension, hypertriglyceridemia and insulin resistance)

As the below OmegaCheck lab results clearly indicate both patients were significantly depleted in Omega-3 fatty acids and it would be prudent to recommend Omega-3 fatty acids in these two cases.

The optimal level I strive to achieve when ordering the OmegaCheck is 8.

The Safety of Fish Oil Supplements: It is Complicated and In the Details

The motto is clear: You don't want to take fish oil if you don't need them. It really is as simply as that.

I have another motto: Test Don't Guess

Dr. Grisanti's Comments and Recommendations

Regular use of fish oil supplements have different roles in cardiovascular health, disease progression, and death.

Fish oil supplements might be a risk factor for atrial fibrillation and stroke among the general population but could also be beneficial to reduce the progression of cardiovascular disease.

Again I have outlined in this important article, I DO NOT randomly prescribe fish oils without first ordering the OmegaCheck from either Labcorp or Quest.

The OmegaCheck is part of my cardiovascular lab panel on most ALL patients.

It has proven to be an extremely valuable test to determine if a patient is in need of extra omega 3 fatty acids supplementation or if they should not increase their usage of fatty acid supplementation.

Of course I strongly recommend rechecking your patients OmegaCheck in 90 days after the patient begins taking extra omega 3 fatty acids if indeed you find they are deficient.

When you see the OmegaCheck is approximately at the 8 level, then back off on the omega 3 fatty supplements and consider a lower maintenance level.

I recommend getting omega-3 fatty acids from food such as sardines, mackerel, anchovies and wild-caught salmon.

I do not recommend farm-raised salmon because of impurities in the water in which they are raised. This may be a bold statement but farm-raised salmon is simply unhealthy for human consumption and does not have the levels of omega 3 fatty acids that wild-caught salmon has.

The Issue of Obtaining Omega 3 Fatty Acids from Eating Flaxseed and Chia Seeds.

Although I am a proponent of a plant based/Mediterranean diet, I have discovered to my discouragement that regular consumption of flaxseed and chia seeds does indeed have many health benefits however the conversion rate from alpha-linolenic acid (ALA) to eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) is low and inconsistent. Remember many plant based proponents have claimed that eating flaxseed and chia seeds is the solution to increasing Omega 3 fatty acids because the ALA found in flaxseeds and chia seeds will easily convert to EPA and DHA.

I will have to disagree on the above statement.

In fact while most research suggests a conversion rate of ALA to EPA of 5%, some research has suggested the conversion rate can be lower and even zero. The key point is that individuals consuming Flaxseeds and chia seeds with the intention of obtaining meaningful levels of Omega-3 fatty acids will not be fulfilling their aims through such products.

In short, consuming even large quantities of Flaxseed, Chia seed may well be good for you generally, but as sources of bioavailable Omega-3s, probably not so useful.

Again I have seen a significant number of patients including both my wife and I following plant based/Mediterranean diet experiencing significant health benefits but showing significantly low levels of omega 3 fatty acids via the OmegaCheck.

I now take only 1 gram of Omega Fatty Acid supplements and consume sardines twice a week.

This has consistently raised almost all of my patients OmegaCheck to 8 Level.

I encourage you to read my recently published paper titled:

Understanding The Three-Legged Stool Concept to Winning the War on Cardiovascular Disease

https://www.functionalmedicineuniversity.com/Grisanti-CardiovascularArticle.pdf

https://www.functionalmedicineuniversity.com/public/1998.cfm

========

References:

https://bmjmedicine.bmj.com/content/3/1/e000451
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756005/
https://www.cedars-sinai.org/newsroom/omega-3-supplements-could-elevate-risk-of-atrial-fibrillation/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175873/
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.058596
https://jamanetwork.com/journals/jama/fullarticle/2777450
https://pubmed.ncbi.nlm.nih.gov/35647665/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023944/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674268/
https://www.clinicalnutritionjournal.com/article/S0261-5614(20)30381-2/fulltext (copy and paste link in browser)
https://www.atherosclerosis-journal.com/article/S0021-9150(13)00614-X/fulltext (copy and paste link in browser)
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00336/full
https://www.sciencedirect.com/science/article/abs/pii/S1098882317300485
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872768/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496233/

** Always consult with a physician or healthcare practitioner with significant integrative or functional medicine training before starting any of the above recommendations.

You can find a qualified and certified functional medicine practitioner by going to: www.FunctionalMedicineDoctors.com

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Grisanti and his functional medicine community. Dr. Grisanti encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Visit www.FunctionalMedicineUniversity.com for more information on our training in functional medicine. Look for practitioners who have successfully completed the Functional Medicine University's Certification Program (CFMP) www.functionalmedicinedoctors.com. This content may be copied in full, with copyright, contact, creation and information intact, without specific permission, when used only in a not-for-profit format. If any other use is desired, permission in writing from Dr. Grisanti is required.

The Simple Blood Test That Could Save Your Heart and Brain

Homocysteine

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Elevated levels of homocysteine in the blood are associated with an increased risk of cardiovascular and neurological diseases.

Maintaining optimal homocysteine levels is crucial for overall health, as high levels can lead to inflammation and damage to blood vessels.

Why Test for Homocysteine?

Studies have found elevated homocysteine levels in almost 30% of people older than 65 and more than 40% in people 80 and older.

High levels of homocysteine commonly referred to as hyperhomocysteinemia has long been established as a risk factor for ischemic heart disease, heart attack, sudden cardiac death, premature coronary artery disease, carotid artery stenosis (narrowing), blot clots, stroke, and peripheral vascular disease.

Newer studies have also identified high homocysteine as an independent risk factor for dementia and cognitive impairment.

Homocysteine levels higher than 15 µmol/L are associated with nearly double the prevalence of dementia.

A 2017 study showed that patients with Parkinson's disease and cognitive dysfunction were more likely to have higher homocysteine levels.

By measuring homocysteine levels, healthcare practitioners can be proactive in their health management, aiding in the prevention of serious medical conditions and promoting overall well-being.

Homocysteine- LabCorp code: 706994

Understanding Homocysteine Test Results

Normal and optimal homocysteine levels should be less than 10 µmol/L.

Levels between 10-15 µmol/L are considered borderline.

Hyperhomocysteinemia is diagnosed with a serum homocysteine level greater than 15 µmol/L. T

Here are three classifications of hyperhomocysteinemia:

Moderate: 16-30 µmol/L
Intermediate: 31-100 µmol/L
Severe: > 100 µmol/L

Causes of Elevated Homocysteine Levels

Factors that can compromise homocysteine metabolism and contribute to elevated levels include:

Comorbid medical conditions: cancer, diabetes, kidney disease, thyroid dysfunction, homocystinuria
Folate, vitamin B6, and vitamin B12 deficiencies (most common)
Dietary factors: excess consumption of alcohol, coffee, and methionine-rich foods
Genetic variations of the cystathionine β-synthase (CBS) and methylenetetrahydrofolate reductase (MTHFR) genes
Older age

Health Concerns of High Homocysteine

Elevated levels of homocysteine damage the inner endothelial lining of blood vessels, promoting inflammation and oxidative stress in the vasculature. This increases the risk of atherosclerosis, a thickening and hardening of arteries caused by plaque buildup, and blood clots.

A diagram of a human heart

Description automatically generated

Reference: https://www.sciencedirect.com/science/article/pii/S2666053923000413?via%3Dihub

There is growing evidence that homocysteine is neurotoxic and decreases blood perfusion to the brain. Elevated levels are associated with neurodegeneration progression, as observed in diseases like Alzheimer's disease.

Strategies to Lower Homocysteine Levels

Addressing high homocysteine through dietary modifications includes moderating alcohol and coffee consumption and adequately consuming foods rich in folate, vitamin B6, and vitamin B12.

Some of the foods with the highest content of these vitamins are listed below:

Folate: spinach, liver, asparagus, and brussels sprouts
Vitamin B6: fish, organ meats, potatoes, non-citrus fruits
Vitamin B12: fish, meat, poultry, eggs, dairy

Eating a high-protein diet has also been shown to elevate homocysteine levels. Methionine is found in high quantities in the standard American diet, concentrated in foods like meat, fish, poultry, dairy, and eggs. Limiting the intake of these foods may prevent hyperhomocysteinemia.

Supplements to Lower Homocysteine Levels

Studies have demonstrated the efficacy of B vitamin supplementation in reducing homocysteine levels.

If your homocysteine is over 10 micromoles per liter, you can lower it by taking B6, B12 and folate. If your homocysteine is above 10 start by taking the pyridoxal-5-phosphate (P5P) form of vitamin B6, 20-to 50 milligrams each day; the methylcobalamin (methyl-B12) and adenosylcobalamin forms of B12, 1 milligram in total each day; and the methyltetrahydrofolate (methyl-folate), starting with 0.8 milligrams (and as high as 5 milligrams) each day.

After three months, recheck the homocysteine to make sure it has dropped to 10 micromoles per liter or lower. In the uncommon cases in which it hasn't, simply add 500 milligrams daily of glycine betaine (also called trimethylglycine).

Re-check homocysteine in another three months.

If still high reduce the methionine (the amino acid from which the body makes homocysteine) in your diet by limiting consumption of foods such as nuts, beef, lamb, cheese, turkey, pork, shellfish, soy, eggs, dairy and beans.

Research suggests that omega-3 fatty acids effectively reduce homocysteine levels, especially when simultaneously taken with B vitamins.

Oral N-acetyl cysteine (NAC) supplementation may be considered for preventing vascular events and treating hyperhomocysteinemia. Four weeks of oral NAC dosed at 1.8 grams daily resulted in reductions of serum homocysteine by 11.7% and significant reductions in systolic and diastolic blood pressure.

Dr. Grisanti's Comments

In addition to checking your a blood homocysteine test, I also recommend getting your methylmalonic acid (MMA) tested. This is the most specific test for B12 status NOT the serum B-12 blood test.

Methylmalonic Acid (MMA), Serum-LabCorp Code: 706961
Methylmalonic Acid (MMA), Random Urine: 716365

Does MTHFR cause high homocysteine?

The MTHFR gene, which stands for methylenetetrahydrofolate reductase, is a relatively common genetic mutation that can affect how the body processes homocysteine. The MTHFR gene produces an enzyme that helps regulate homocysteine levels in the body. When the MTHFR gene is mutated, the enzyme may not function properly, which can lead to higher levels of homocysteine in the blood.

MTHFR C677T and A1298C gene mutations are the most common and the ones that are typically tested.

You may want to check to see if your have MTHFR gene.

Here is the Labcorp Test and Code:

MTHFR, DNA Analysis (Methylenetetrahydrofolate Reductase Thermolabile Variant)- LabCorp Code: 511238

References:

https://pubmed.ncbi.nlm.nih.gov/15218538/
https://www.ncbi.nlm.nih.gov/pubmed/8929261 ;
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/226081
https://www.sciencedirect.com/science/article/pii/S0002916523279411?via%3Dihub
https://www.sciencedirect.com/science/article/pii/S0002916523137397?via%3Dihub
https://www.sciencedirect.com/science/article/abs/pii/S0899900711000098?via%3Dihub
https://www.jstage.jst.go.jp/article/jcbn/64/3/64_17-56/_article
https://www.sciencedirect.com/science/article/pii/S1096719220300512?via%3Dihub
https://onlinelibrary.wiley.com/doi/10.1111/bcpt.12424
https://www.sciencedirect.com/science/article/pii/S2213231719309589?via%3Dihub
https://www.sciencedirect.com/science/article/abs/pii/S0304394016308461?via%3Dihub
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-01977-8

** Always consult with a physician or healthcare practitioner with significant integrative or functional medicine training before starting any of the above recommendations.

You can find a qualified and certified functional medicine practitioner by going to: www.FunctionalMedicineDoctors.com

Additional Labs to Track for Cardiovascular Disease

Additional Lab Markers to Track and Monitor for Cardiovascular Disease

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Today's article focuses on the value of tracking and monitoring the basic complete blood count (CBC) as it relates to increased cardiovascular events.

It is recommended to consider taking a deeper look at the components of the CBC blood levels, especially white blood cells (WBC), hemoglobin, platelets, mean corpuscular volume (MCV) and red cell distribution width (RDW).

Most physicians do not commonly relate abnormally high levels of the above CBC markers and increased cardiovascular disease but the peer reviewed literature proves otherwise.

Here are the CBC components I recommend you review on your most recent or past lab work.

WBC above 9 thousand increases risk of heart attack by 4x
If hemoglobin is high so is blood pressure
RDW above 14.5 increases cardiovascular risk
MCV above 95 = 25% higher CVD risk
Platelet count above 400 = 50% higher risk of CVD

Action Steps to Take To Improve Cardiovascular Risk

Rule out B-12 and folate deficiency
Curb systemic inflammation
Drink plenty of filtered or spring water
Rule out infection

Comments

Although this is a small component of looking at other cardiovascular markers, I suggest seeking the expertise of a doctor trained in functional medicine who can perform a more comprehensive review of your cardiovascular health and outline an effective diagnostic and treatment plan.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224537/
https://pubmed.ncbi.nlm.nih.gov/11590089/
https://www.sciencedaily.com/releases/2005/03/050323134019.htm
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.045102
https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.84.2.613
https://www.frontiersin.org/articles/10.3389/fcvm.2019.00109/full
https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.112.193565
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261384/

An Important Overlooked Cardiovascular Lab

An Important Overlooked Cardiovascular Lab Test Most Cardiologists Do Not Check (but Should)

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

For most people, cholesterol has been considered the cardiovascular lab test to monitor your risk of a cardiovascular event. However, increased cholesterol levels were found in less than 50% of all heart attack and stroke victims.

Researchers at the World Health Organization published a study that pointed to an overlooked risk factor that seemed to account for the other half.

It was a blood marker known as fibrinogen.

Now, to understand just how dangerous excess levels of this blood marker can be we must first look at how it works in your bloodstream.

Fibrinogen is a protein produced by the liver and in small quantities is an absolute vital component for survival. When you cut or scrape your skin, fibrinogen is the agent which causes the blood to thicken and eventually create a scab which clots the wound altogether. It also works in your arteries by creating small clotting agents that patch up cracks and crevices from inflammation.

The problem begins when levels of fibrinogen become elevated. When this occurs, instead of creating a small clot to repair the arterial damage, the fibrinogen begins to create an adverse event by creating a much larger clot than is needed. These oversized clots can grow to the point where they close off veins, blood vessels or major arteries entirely and cause heart attacks and stroke.

A Harvard University Study published in the Journal of the American College of Cardiology found that “Those with high fibrinogen levels had a twofold increase in myocardial infarction (heart attack) risk.”

And still another study published in the prestigious Royal College of General Practitioners found that when coupled with other heart-health risk factors such as cholesterol and high blood pressure, “incidence of heart attacks was respectively six times and 12 times greater in those with high plasma fibrinogen levels than in those with low fibrinogen levels.”

In other words, even if you have high cholesterol or high blood pressure you're respectively 600% and 1200% less likely to suffer a heart attack if your fibrinogen levels are in line!

Assessing your risk

Your levels of fibrinogen can be easily tested by any doctor simply by asking for what's called a fibrinogen activity test.

I like to see my patients' fibrinogen levels under 300 mg/dl. If your levels are lower, I'd continue to get your levels tested around twice a year. If higher, you should get your levels tested every three months.

How to Lower Your Fibrinogen Levels

1. Follow a strict Mediterranean diet

2. Consume foods high in omega 3 (EPA and DHA) I recommend taking a supplement with between 2-3 grams per day. The following foods are rich in Omega 3's such as wild salmon, mackerel and sardines and avocados. Also eat plenty of nuts and seeds such as macadamia nuts, pecans, walnuts, and flaxseeds. And use macadamia nut oil, estate-bottled olive oil, and avocado oil.

3. Take Nattokinase and Serratiopeptidase

Word of Caution.

Always check with your physician if you are on blood thinning medication which increases your risk for bleeding episodes.

References:

Compliments of www.FunctionalMedicineUniversity.com

Atrial Fibrillation and Dental Care

Atrial Fibrillation & Dental Care

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

This article provides evidence revealing dental infections such as periodontitis, gingivitis, and endodontic lesions may be linked to cardiovascular disease, atrial fibrillation, and cardiac arrhythmia.

Atrial fibrillation (AF) is the most common persistent cardiac arrhythmia occurring in clinical practice.

Oral bacteria and/or their DNA have been detected in human atherosclerotic lesions, the pericardial fluid, heart valves, and thrombi in many studies. A recent meta-analysis of 63 studies that included 1791 patients confirmed the presence of 23 oral bacterial species in atherosclerotic plaques. Campylobacter rectus, Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia, and Prevotella nigrescens.

Patients affected by oral infections are exposed to many toxins, metabolic products, and proteins of bacterial origin, which may influence the myocardium.

Inflammation, as well as atrial electrical and structural remodeling, is suggested to play a role in the initiation and perpetuation of AF.

It is recommended to consider dental infections in patients suffering with AF.

A good dental work-up is consider wise medicine when dealing with AF.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164509/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087888/
https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13875

Compliments from Functional Medicine University www.FunctionalMedicineUniversity.com

Bacteria Linked to Atherosclerosis

Bacteria Linked to Atherosclerosis in the Most Unexpected Place

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Medical literature is very clear that oral dental health plays a significant role in your cardiovascular health.

As odd as it sounds, regularly brushing and flossing your teeth could be what stands between you and a future heart attack.

Research has linked bacteria from the Streptococcus genus to fatty plaque buildup in heart arteries.

A new study published in the journal Circulation has pinpointed two specific oral microorganisms that play a role in whether we develop atherosclerosis (clogged arteries).

In all people there should be a healthy balance of good and bad bacteria in our mouth (teeth). However when this balance is upset, it kicks off a chain of events that makes atherosclerosis far more likely to occur.

The researchers used advanced technology for the study to reexamine the gut and oral bacteria assessments and cardiac imaging from 8,973 volunteers in the earlier SCAPIS study.

Search in the medical literature has actually identified three bacteria associated with atherosclerosis when they were found in large numbers in the mouth. They include:

Streptococcus anginosus
Streptococcus oralis
Streptococcus mutans

The scientists who have published their research have two theories about why these bacteria might be a contributing factor for atherosclerosis.

1:These bacteria (streptococcus species) set off systemic low-grade inflammation that leads to plaque accumulation in heart arteries.

2: In an attempt to evade our immune system, the bacteria in our mouth enter our bloodstream and set up shop in our arteries.

Steps to take to decrease the potential of Streptococcus genus compromising our cardiovascular health include:

1. Regularly brushing your teeth

2. Flossing

3. Consider using a waterpik water flosser (this is my dentist strongest recommendations to clean out bacteria deep in the back molars.) This oral health appliance provides a stream of pulsating water to floss between your teeth and below the gumline.

4. Don't forget the most important step of ideal dental health and that is regular dental cleanings.

Here are some additional recommendations to be certain your oral health has the best opportunity to be bacteria free.

1. Stop the Sugar

2. Salt Water Rinse

3. Tea Tree Oil and/or Oregano oil products. These essential oils have natural antibacterial qualities. If you battle gingivitis, look for mouthwash or toothpaste made with tea tree oil (never use straight oil) and/or Oregano oil.

4. Olive Leaf Extract: Olive leaf extract is another natural antibacterial that can be used in mouthwash or toothpaste.

5. One of my personal go to preventive measures to ensure optimal oral health is the Dentalcidin Oral Care System by Biocidin Botanicals. Clear here for more details on this dental care system.

Start protecting your heart and reducing your risk of heart complications today by focusing on your oral care.

You can find a qualified and certified functional medicine practitioner by going to: www.FunctionalMedicineDoctors.com

References:

https://www.sciencedirect.com/science/article/pii/S1882761608000045
https://www.sciencedirect.com/science/article/abs/pii/S1043276015000454
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1594668/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275337/
https://pubmed.ncbi.nlm.nih.gov/33825326/
https://journals.asm.org/doi/full/10.1128/iai.00897-19
https://pubmed.ncbi.nlm.nih.gov/37435755/

Compliments from Functional Medicine University www.FunctionalMedicineUniversity.com

Benefits of Aged Garlic and Heart Health

Benefits of Aged Garlic & Heart Health

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Medical research in human populations has consistently found that chronic inflammation has been linked to increased risk for cardiovascular disease as well as other illnesses.

Scientists at Sweden's Skane University Hospital and Lund University recently found that a daily dose of Kyolic Aged Garlic Extract (AGE) effectively reduced two key inflammatory biomarkers (interleukin-6 (IL-6) and C-Reactive Protein (hs). These markers have been found to be closely associated with the development and progression atherosclerosis.

The Sweden study was further confirmed by Dr. Mathew Budoff, a cardiologist and professor of medicine at UCLA. Dr. Budoff, stated that AGE is further proof showing multi-factorial improvement in inflammation and having the potential to improve clinical outcomes of atherosclerosis and heart disease

The Swedish researchers also have found that AGE had additional positive clinical findings. These include:

AGE increased blood flow through the tiny capillaries that feed the tissues in the body's extremities which would aid in wound healing in those suffering from atherosclerosis and other vascular diseases.
AGE inhibits the progression of plaque formation in those who already suffer from cardiovascular disease.
AGE lowered glucose levels
AGE reduced the number of colds by a whopping 63%.
AGE lowered blood pressure. One study showed that taking 600-1,500 milligrams of AGE was just as effective as the hypertension drug atenolol in reducing blood pressure over a 24-week period.
AGE has the potential to reduce dementia risk.

My suggestion is consider the following two brands for your garlic consumption:

GARLINEX from Longevinex
Kyolic Aged Garlic Extract

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032523
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652202
https://pubmed.ncbi.nlm.nih.gov/33868439
https://academic.oup.com/jn/article/149/4/605/5428122
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966106
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946235/
https://pubmed.ncbi.nlm.nih.gov/16484570/
https://www.youtube.com/watch?v=3FVR5U8d9gw

Compliments of Functional Medicine University www.FunctionalMedicineUniversity.com

Congestive Heart Failure

Congestive Heart Failure--Traditional and Alternative Approach

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Heart failure — sometimes known as congestive heart failure — occurs when the heart muscle doesn't pump blood as well as it should. When this happens, blood often backs up and fluid can build up in the lungs, causing shortness of breath.

Heart failure signs and symptoms may include:

Shortness of breath with activity or when lying down
Fatigue and weakness
Swelling in the legs, ankles and feet
Rapid or irregular heartbeat
Reduced ability to exercise
Persistent cough or wheezing with white or pink blood-tinged mucus
Swelling of the belly area (abdomen)
Very rapid weight gain from fluid buildup
Nausea and lack of appetite
Difficulty concentrating or decreased alertness

Recommended testing for Heart Failure:

NT-proB-type Natriuretic Peptide (BNP) blood test. B-type natriuretic peptide (BNP) is a hormone produced by your heart. Levels goes up when heart failure develops or gets worse, and levels goes down when heart failure is stable. In most cases, BNP and NT-proBNP levels are higher in patients with heart failure than people who have normal heart function.

A normal level of NT-proBNP, based on Cleveland Clinic's Reference Range is:

Less than 125 pg/mL for patients aged 0-74 years
Less than 450 pg/mL for patients aged 75-99 years

If you have heart failure, the following NT-proBNP levels could mean your heart function is unstable:

Higher than 450 pg/mL for patients under age 50
Higher than 900 pg/mL for patients age 50 and older

Echocardiogram

Ejection fraction (EF): Your EF is a measurement of the blood pumped out of your heart with each beat. A normal EF is between 55% and 70%

The Role of C-Reactive Protein (CRP) in Heart Failure

Some studies show that CRP is increased in heart failure. Higher levels are associated with features of more severe heart failure and are independently associated with mortality and morbidity.

Traditional Medical Treatments:

The newer combination drug called Sacubitril-valsartan (Entresto) (called an ARNI, ARB with a Neprilysin Inhibitor) has been studied and shown to have improved outcomes in patients with a weak heart muscle when it replaces medications like lisinopril (an ACE Inhibitors) or losartan (an ARB, or Angiotensin Receptor Blocker). For patients with a heart muscle with reduced ejection fraction (EF< 40%), Quadruple therapy is the recommended:

An ACE Inhibitor, ARB or ARNI
A Beta blocker (carvedilol or metoprolol succinate)
An Aldosterone antagonist (spironolactone or eplerenone)
An SGLT2 Inhibitor (dapagliflozin)

Alternative Medicine Considerations in the Management of Heart Failure

Of the many adjunctive treatments for congestive heart failure (CHF), four of the most widely publicized in recent years are Q10 (ubiquinol) 100 mg to 300 mg/day, hawthorn, ribose (5 grams per day) and carnitine. More studies need to be conducted.

Dr. Grisanti Comments: I recommend rechecking the BNP after six weeks on the above alternative protocol. As always work with the patient's cardiologist or primary physician to provide both a traditional and alternative approach to this serious disease. I have personally received acceptance with my patient's doctors with little push back on the above recommendations. The key is to be fully transparent in your clinical management and DO NOT NEGLECT the importance of traditional medicine. Obtaining a reduction in the BNP with improved subjective findings only reinforces your acceptance within the framework of the medical arena. Remember most if not all physicians want to see both objective and subjective improvements and adhere to the Hippocratic oath First Do No Harm.

References

https://www.ahajournals.org/doi/10.1161/circulationaha.104.508465
https://pubmed.ncbi.nlm.nih.gov/30114262/
https://pubmed.ncbi.nlm.nih.gov/16129801/
https://www.karger.com/Article/Fulltext/351115
https://www.aafp.org/afp/2000/0915/p1325.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287951/
https://www.ahajournals.org/doi/full/10.1161/CIRCHEARTFAILURE.115.002639
https://www.sciencedirect.com/science/article/pii/S0019483217308696
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249900/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716264/
https://www.sciencedirect.com/science/article/abs/pii/S0002914922004362
https://pubmed.ncbi.nlm.nih.gov/1538579/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406747/

Compliments of Functional Medicine University www.FunctionalMedicineUniversity.com

Glyphosate (RoundUp) & Cardiovascular Disease

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Glyphosate is a worldwide commonly used herbicide and is the primary toxic chemical in Roundup™, as well as in many other herbicides.

A growing number of clinical studies have discovered glyphosate exposure to be a cause of many chronic health problems including heart disease.

It can enter the body by direct absorption through the skin, by eating foods treated with glyphosate, or by drinking water contaminated with glyphosate.

Some studies have shown cardiac electrophysiological changes associated to glyphosate.

Glyphosate exposure has been implicated as the potential cause of diffuse electrophysiological depolarization and repolarization conduction abnormalities, including prolonged QTc, intraventricular block, and AV conduction delay. These changes can lead to the development of life-threatening arrhythmias.

Some studies suggests that glyphosate has atherogenic potential, regardless of the concentration and route of exposure. It is recommended to considered testing your patients suffering cardiovascular challenges for glyphosate exposure.

Testing for Glyphosate

Treatment:

There are several things you can do to minimize — and even eliminate — glyphosate contamination

The most effective way to reduce glyphosate exposure is to avoid living in areas where glyphosate is applied and to avoid eating GMO foods or animal products such as milk or meat for which GMO foods were used to feed the animals.

It must also be emphasized to eat organic produce!

The following should also be included in your glyphosate detox protocol:

1. Citrus pectin

2. Alginates (purified from kelp)

3. Glycine

4. Gingko biloba

5. Organic Iceland kelp

6. Probiotics and prebiotics

7. Infrared sauna

References

https://journals.sagepub.com/doi/abs/10.1177/0748233721996578
https://www.heartrhythmcasereports.com
https://jphe.amegroups.com/article/view/3665/4415
https://www.greatplainslaboratory.com/glyphosate-test
https://draxe.com/health/glyphosate-toxicity/

www.FunctionalMedicineUniversity.com

Heart Failure & Galectin 3

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Heart failure constitutes an important medical, social, and economic problem. The prevalence of heart failure is estimated as 2–3% of the adult population and increases with age, despite the scientific progress of the past decade.

It is now known that 30 to 50% of patients with increased galectin-3 levels have progressive or remodeling form of heart failure.

Galectin-3 (Gal-3) lab levels are significantly increased in chronic heart failure.

In addition to the traditional lab test, B-type natriuretic peptide (NTproBNP), Gal-3 should now also be considered to test for heart failure.

Galectin-3 has been known for its significant role in mediating cardiac fibrosis and inflammation.

Its main action is to bind to and activate the fibroblasts that form collagen and scar tissue, leading to progressive cardiac fibrosis.

There are now hundreds of published pre-clinical and observational human studies indicating that Gal-3 is both a predictive biomarker and treatment target in CVD, as well as in other inflammatory and fibrotic conditions.

There is now progressive research showing that modified citrus pectin (MCP)—can bind to circulating Gal-3 and block its deleterious effects.

Modified citrus pectin (MCP) has been shown to inactivate galectin-3, blocking its ability to send destructive molecular signals throughout the body.

In essence, modified citrus pectin (MCP), a soluble dietary fiber found in citrus fruit, is a direct Gal-3 inhibitor.

I recommend PectaSol powder.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433562
https://onlinelibrary.wiley.com/doi/10.1111/1440-1681.13048
https://www.ahajournals.org/doi/10.1161/circheartfailure.111.963637
https://www.sciencedirect.com/science/article/pii/S1875213613002775
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838053/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961642/
https://www.fxmedicine.com.au/podcast/galectin-3-new-target-inflammation-dr-issac-eliaz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072992/
https://pubmed.ncbi.nlm.nih.gov/32172066/

www.FunctionalMedicineUniversity.com

How to Decrease Arterial Stiffness

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Atherosclerosis is a disease of the arteries that leads to accumulations of fat cells, and calcium deposits (i.e. plaques). It has been shown that people with a rapid increase in the amount of calcium deposits have a higher risk for stroke and heart attack than people with a decreased amount.

Vitamin K2 is associated with the inhibition of arterial calcification and arterial stiffening. An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls

In the groups receiving high-dose vitamin K2 (MK-4), not only was there no further arterial calcium accumulation, there was a 37% reduction of previously accumulated arterial calcification after six weeks. After 12 weeks, there was a 53% reduction in accumulated arterial calcium deposits.

Conclusion:

Medical peer reviewed papers support considering adding vitamin K2 to a healthy lifestyle protocol (cardio/resistant exercise, Paleo-Diet, relaxation, flexibility exercises, etc.) to reverse the damaging effects of arterial calcification and arterial stiffening.

References

https://www.healthline.com/nutrition/vitamin-k2#bottom-line
https://www.lifeextension.com/magazine/2017/11/vitamin-k-and-arterial-stiffness
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.12157
https://clinicaltrials.gov/ct2/show/NCT04010578
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566462/
https://pubmed.ncbi.nlm.nih.gov/26176325/
https://www.sciencedaily.com/releases/2009/10/091006093345.htm

Compliments of

www.functionalmedicineuniversity.com

Is Your Teen at Risk of Dying from Heart Failure?

Is Your Teenager At Risk of Dying From Heart Failure? What Every Parent MUST Know

Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S., CFMP

An athletic 20-year-old man is playing basketball and suddenly collapses on the court and dies.

On a hot July day, a young and vibrant college football player suddenly makes a great tackle and never gets up.. only to be pronounced dead 5 minutes later.

High School track runner dies after finishing second in a race.

The sad truth is that 1 out of 50,000 young adults will fall victim to Sudden Death.

Most sudden deaths have been linked to a thickened, enlarged heart called hypertrophic cardiomyopathy (HCM), or by a condition that disturbs the rhythm of the heart called an arrhythmia.

When one sweats, a significant amount of magnesium is lost.

Magnesium is the most under-recognized electrolyte disorder in the U.S. Dr. Mildred Seelig, one of the country's leading authorities on magnesium suggests that 80%-90% of the population is deficient is magnesium

It is beyond the extent of this article why the public is being denied the truth of the seriousness of magnesium deficiency and sudden death. The amount of medical research could fill a book, but it is unfortunately being ignored.

According to Micheal A. Brodsky M.D., associate professor of medicine at the University of Medicine and the director of the Cardiac Arrhythmia Service at the University of California, mineral imbalances interfere with the heart's normal nerve function.

While most athletes have been conditioned to drink a potassium rich drink after sweating, very few have been educated on the dangers of a magnesium deficiency. Dr. Brodsky states that arrhythmia therapy should focus on replenishing two key minerals: potassium and magnesium.

Almost all physicians have known for some time just how vital potassium is for normal heartbeat.

Magnesium is an entirely different story, however. According to Carla Sueta M.D., Ph.D., assistant professor of medicine and cardiology at the University of North Carolina at Chapel Hill School of Medicine "apparently, many doctors still don't realize how important a role this mineral can play in some heart patients.

In fact, most never check the magnesium level. She has shown through her research that magnesium reduced the incidence of several types of ventricular arrhythmia by 53 to 76 percent.

Magnesium deficiency can be induced by the very drugs meant to help heart problems. Some types of diuretics (water pills) cause the body to excrete both magnesium and potassium, as does digitalis.

And magnesium deficiency is often at the bottom of what's called refractory potassium deficiency. The amount of magnesium in the body determines the amount of a particular enzyme that determines the amount of potassium in the body," he explains. So if you are magnesium-deficient, you may in turn be potassium-deficient, and no amount of potassium is going to correct this unless you are also getting enough magnesium.

The Best Test To Determine Your Level of Magnesium

Although most physicians rarely check this important mineral, the few that do usually rely on test called Serum Magnesium. Unfortunately, this test only measures approximately 1% of the magnesium in your body; a poor test at best. The "Gold Standard" and the most accurate test is the red blood cell (RBC) elements tests.

This test examines the levels of twelve minerals and six toxic heavy metals. The erythrocyte is the red blood cell that floats in our serum to carry oxygen to our cells.

The minerals this test analyzes from inside the red blood cell includes magnesium, calcium, copper, potassium, selenium, and zinc.

https://www.doctorsdata.com/Red-Blood-Cell-Elements

Common Symptoms of Magnesium Deficiency

The most common symptoms include back and neck pain, muscle spasms, anxiety, panic disorders, Raynaud's spastic vessels, arrhythmia, fatigue, eye twitches, vertigo, migraines.

Best Sources of Magnesium

The best way of insuring enough magnesium is to eat a variety of whole foods, including whole grains, nuts, seeds and vegetables, preferably food grown on naturally composted soil. The green color of green vegetables is due to chlorophyll, which is a molecule that contains magnesium. Avoid refined processed foods, especially white sugar and white flour products, as most magnesium is removed from them.

Here is an excellent form of magnesium I recommend

NutriCology's Magnesium Chloride Liquid 8 fl oz

Dr. Grisanti's Comments:

If you are suffering with a heart problem and have not had your magnesium checked, then I want to urge you to have your physician order the two tests listed above. Unless you have proof that your magnesium is within normal levels, I want you to realize that you are playing with your health!

References

Eisenberg MJ, Magnesium deficiency and sudden death (editorial), AM Heart J 1992 Aug; 124(2):544-9

Magnes Res 1994 Jun;7(2):145-53

Tzivoni, Dan, M.D. and Keren, Andre, M.D., "Suppression of Ventricular Arrhythmias by Magnesium", The American Journal of Cardiology, June 1, 1990;65:1397-1399.

Miner Electrolyte Metab 1993;19(4-5):323-36

Keller, Peter K. and Aronson, Ronald S., "The Role of Magnesium in Cardiac Arrhythmias", Progress in Cardiovascular Diseases, May/June 1990;32(6):433-448.

Biochim Biophys Acta 1993 Oct 20;1182(3):329-32

Biochim Biophys Acta 1994 Jan 11;1225(2):158-64

Practical Briefings: Clinical News You Can Put Into Your Practice Now. Ventricular Arrhythmias and Magnesium", Patient Care, October 15, 1990;16-20

Magnes Res 1993 Jun;6(2):191-2

Hennekens (1987) Epidemiology Medicine, p.54-98

Schriftenr Ver Wasser Boden Lufthyg 1993;88:474-90

Am J Cardiol 1992 Oct 8;70(10):44C-49C

Fiziol Zh SSSR Im I M Sechenova 1992 Jul;78(7):71-7

Compliments of

www.functionalmedicineuniversity.com

Macadamia Nuts Enhance Heart Health

Macadamia Nuts-- The King of Tree Nuts

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

When it comes to eating tree nuts the king is Macadamia Nuts.

They are nutritional powerhouses that set themselves apart from the rest because of their high monounsaturated fat, thiamin, and manganese content.

A Nutrient Breakdown of Macadamia Nuts: A True Nutritional Powerhouse

Here's an overview of the nutrients we get from 1 ounce of raw macadamia nuts (28 grams or 10 nuts):

203.5 Calories
3.9 g Carbohydrate
2.4 g Fiber
1.5 g Net Carbs
21.5 g Fat
16.7 g Monounsaturated Fatty Acids
2.2 g Protein
0.34 mg Thiamin (23% DV)
0.05 mg Riboflavin (3% DV)
0.7 mg Niacin (4% DV)
0.21 mg Vitamin B5 (2% DV)
0.08 mg Vitamin B6 (4% DV)
24.1 mg Calcium (2% DV)
0.21 mg Copper (11% DV)
1.05 mg Iron (6% DV)
36.9 mg Magnesium (9% DV)
1.17 mg Manganese (59% DV)
104.3 mg Potassium (3% DV)
1.02 mcg Selenium (1% DV)

5 Science-Backed Benefits of Macadamia Nuts

1: Improves Brain Function

Macadamia nuts contain more healthy monounsaturated fatty acids than any other nut. Two of these monounsaturated fats are known for their brain-boosting benefits: oleic acid and palmitoleic acid.

2: Enhances Heart Health

Not only do the monounsaturated fats found in macadamias boost brain health, but they also help improve most of the biomarkers associated with heart disease risk (i.e., triglycerides, blood pressure, and cholesterol levels).

3: Improves Blood Sugar Regulation

The high amount of palmitoleic acid found in macadamia nuts has been found to increase insulin sensitivity, which plays a major role in preventing the onset of type 2 diabetes.

4: Reduces Inflammation

5: Supports Gut Health

The soluble fiber in macadamia nuts aids your digestion by feeding your beneficial gut bacteria. In turn, this can improve your gut health.

Summary:

Although all nuts are healthy in some way, it can be argued that the macadamia nut is the healthiest nut.

Let's take a look at some of the advantages that macadamias have over most nuts:

They are lower in carbs and net carbs than most nuts.
They contain the most thiamin (vitamin B1) compared to other commonly consumed nuts.
They have more manganese than most nuts, which helps with nutrient absorption, production of digestive enzymes, bone development, and immune-system defenses.
They contain less protein than most nuts
They provide us with more healthy monounsaturated fats than any other nut.
They have the lowest amount of inflammatory omega-6 fats per serving compared to other commonly consumed nuts.

References:

https://pubmed.ncbi.nlm.nih.gov/18356332/
https://pubmed.ncbi.nlm.nih.gov/15649284/
https://pubmed.ncbi.nlm.nih.gov/12672919/
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.29.1_supplement.923.6
https://pubmed.ncbi.nlm.nih.gov/10789609/
https://pubmed.ncbi.nlm.nih.gov/17437143/
https://pubmed.ncbi.nlm.nih.gov/24925120/
https://pubmed.ncbi.nlm.nih.gov/20064680/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646185/
https://www.sciencedirect.com/science/article/abs/pii/S0308814610001378
https://academic.oup.com/jn/article/138/4/761/4665045
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190113/

www.functionalmedicineuniveristy.com

Nattokinase- Cardiovascular Benefits

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Nattokinase is an enzyme that is extracted from a popular Japanese food called natto. Natto is boiled soybeans that have been fermented with a bacterium called Bacillus natto.

Nattokinase has been found to keep blood optimally flowing and promote cardiovascular health.

According to the research on this powerful enzyme, it can lower blood pressure, help reduce the risk of atherosclerosis, help lower lipids, support optimal blood flow with its anticoagulant properties, and may even be neuroprotective.

Nattokinase has the unique ability to dissolve fibrin, a protein that helps our body form clots. As we age, we can experience an increase in blood viscosity or thickness. Blood that is too ‘thick' is more prone to clotting and doesn't flow as easily through the blood vessels. This can increase blood pressure as the heart has to pump harder to circulate the same amount of blood. Nattokinase helps decrease blood viscosity, or thick, sludgy blood and supports healthy blood flow.

Nattokinase has been associated with a decrease in both systolic and diastolic blood pressure.

In 2008 a randomized, double-blind, placebo-controlled trial on nattokinase looked at 86 individuals with high blood pressure. They received nattokinase or a placebo for eight weeks. Seventy-three subjects completed the study, and those taking nattokinase had a significant reduction in blood pressure.

Nattokinase has been found to help with atherosclerosis (hardening of the arteries).

In a 26-week study 82 randomized volunteers took either 300 mg of nattokinase daily or 20 mg every day of the anti-cholesterol medication simvastatin.

In people taking nattokinase, both the arterial wall thickness, and the size of arterial plaques significantly decreased. In the nattokinase group, plaque size decreased by 36.6% compared with only an 11.5% reduction in the simvastatin group.

An added benefit included that volunteers taking nattokinase showed significant reductions in total cholesterol, low-density lipoprotein cholesterol (bad cholesterol) and triglyceride while at the same time their of high-density lipoprotein cholesterol (good cholesterol) increased.

Take Away

Based on my review of the medical literature, adding nattokinase to a cardiovascular protocol has promising value and may in fact be life-saving.

It is suggested that nattokinase could be a good health functional food for the improvement of blood flow.

**Caution Comment

People who take blood thinners, including warfarin need to know that nattokinase may promote bleeding and easy bruising and should consult with their doctor before taking it.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372539/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043915/
https://pubmed.ncbi.nlm.nih.gov/18971533/
https://www.nature.com/articles/hr2008203.pdf?origin=ppub
https://www.youtube.com/watch?v=ug0zwgf4bV0
https://pubmed.ncbi.nlm.nih.gov/28763875/
https://synapse.koreamed.org/articles/1053773

Compliments of

www.functionalmedicineuniversity.com

The Amazing Benefits of Olive Oil

The Amazing Benefits of Olive Oil (Be Aware of Fake Olive Oil)

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Olive Oil is considered a superfood source.

It is rich in healthy monounsaturated fats. The key fatty acid in olive oil is oleic acid. This fatty acid has been found to be responsible for lowering inflammation.

Research also suggests that oleic acid can reduce levels of important inflammatory markers like high sensitivity C-reactive protein (hs-CRP) and Interleukin-6.

Reduced Stroke Events Associated with Consumption of Olive Oil

Thirty-two cohort studies (42 reports) including 841,211 subjects found that olive oil was the only source of monounsaturated fat associated with a reduced risk of stroke.

Cardiovascular Benefits

Olive oil intake has also been shown to lower blood pressure. In one study, olive oil reduced the need for blood pressure medication by 48%.

Study found that a single dose of high polyphenol olive oil increased endothelial function (cells lining the interior of blood vessels), decreased bad” LDL cholesterol from oxidation and moderated blood glucose.

Diabetes Benefits

Several studies have found that olive oil olive oil, combined with a Mediterranean diet, can reduce the risk of type 2 diabetes and improve insulin sensitivity.

Olive Oil and Helicobacter pylori

A study in humans suggested that 30 grams of extra virgin olive oil, taken daily, can eliminate Helicobacter pylori infection in 10–40% of people in as little as two weeks.

The results of lab studies showed olive oil's phenolic compounds were effective against eight strains of H. pylori, including three that are resistant to some antibiotics.

Choose Your Olive Oil Wisely

Turns out many companies that make extra virgin olive oil dilute their product with cheaper, lower grade oils like canola, safflower or sunflower oils.

Brands that passed the University of California test were: Bariani, California Olive Oil, Kirkland Organic, Lucero, Lucini, McEvoy Ranch Organic, Olea Estates Ottavio. Look for the approval California Olive Oil Council (COOC Certified Extra Virgin).

If in doubt you can test for fake olive oils yourself. Simply refrigerate the oil. It should become more solid as it gets colder. If you oil doesn't become thick and cloudy in the refrigerator you know it's probably fake or lower grade oil.

In addition you can look for the seal denoting approval by the California Olive Oil Council, labeled as "COOC Certified Extra Virgin"

Seals of approval from the Italian Olive Grower' Association, the Extra Virgin Alliance (EVA) and UNAPROL also signal a good pure product.

My advice: stick with high quality brands that passed the University of California test of that have earned a seal of approval from one of the organizations I just mentioned.

References:

https://pubmed.ncbi.nlm.nih.gov/23278117/
https://www.nature.com/articles/1602724
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586551/
https://pubmed.ncbi.nlm.nih.gov/25274026/
https://pubmed.ncbi.nlm.nih.gov/8517637/
https://pubmed.ncbi.nlm.nih.gov/13129466/
https://pubmed.ncbi.nlm.nih.gov/15447913/
https://pubmed.ncbi.nlm.nih.gov/15380903/
https://pubmed.ncbi.nlm.nih.gov/10737284/
https://pubmed.ncbi.nlm.nih.gov/19531025/
https://pubmed.ncbi.nlm.nih.gov/22759331/

What's Your Waist to Hip Ratio?

What's Your Waist to Hip Ratio? Your Health Depends on It

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

The waist-to-hip ratio (WHR) is a quick measure of fat distribution that may help indicate a person's overall health.

What does a person's waist-to-hip ratio say about their health?

According to the World Health Organization (WHO), having a WHR of over 1.0 may increase the risk of developing conditions that relate to being overweight, including heart disease and type 2 diabetes.

This may be the case even if other measures of being overweight, such as body mass index (BMI) are in normal range.

The following chart shows how the WHO classify the risk of being affected by weight related health conditions according to WHR:.

What's Your Waist to Hip Ratio? Your Health Depends on It

Impact on Health

Research shows people who are “apple-shaped” are at a greater risk of certain health conditions than those who are “pear-shaped” (when the hips are wider than the upper body).

These health conditions include:

Cardiovascular disease: One study found that abdominal obesity increased the risk of cardiovascular disease and cancer. Another study found the WHR predicted cardiovascular disease more effectively than BMI or waist circumference. A third study found that WHR is a better indicator of risk of mortality from cardiovascular disease than waist circumference alone.

Type 2 diabetes: A 2016 study found that an increased waist circumference was linked to an increased risk of type 2 diabetes.

Fertility: A 2002 study found that women with a WHR of over 0.80 have a lower pregnancy rate than those with a lower WHR, regardless of their BMI.

A 2006 study with almost 15,000 older people (75 years of age or older), it was concluded that "waist to hip ratio" is more important than how much you weigh. The researchers looked at the relationship between waist to hip ratio and Body Mass Index (BMI - how we measure weight for height) and how many people died over the next 6 years.

As it turned out, WHR is even more accurate than BMI for predicting the risks of cardiovascular disease and premature death. In other words, it was "location, location, location" of fat that was most important - not how much you weigh.

More studies include related to WHR and Health Issues include:

A 2021 study found that WHR is an accurate tool for predicting hypertension.

A 2015 study showed that increased WHR is a better indicator than BMI for predicting complications in trauma patients.

A 2018 study shared that a high WHR was a significant predictor of death in women with heart failure.

A 2016 study found that a high WHR was associated with hypertension and diabetes.

The Health Benefits of Decreasing WHR

A 2020 study found that decreasing WHR by 5 percent significantly lowered risks of developing chronic kidney disease in people with nonalcoholic fatty liver disease.

So how do you measure your waist to hip ratio? You need a tape measure and a calculator. Here's how you do it:

1: Measure your waist at the smallest point - usually at the naval or just above it
2: Measure you hips at the widest, largest part
3: Divide your waist measurement by your hip measurement (Waist Measurement ÷ Hip Measurement)

The idea here is that your waist should be smaller than your hips. If your waist is bigger than your hips, than you may have too much fat concentrated around the middle part of your body - something known as "intra-abdominal obesity".

The concept is quite simple here in that intra-abdominal fat is bad for your health.

Conclusion
Measuring a person's WHR is a quick way to get an indication of:

1. Overall health

2. Obesity levels

3. Risk of weight-related health conditions

References:

https://www.acpjournals.org/doi/10.7326/m14-2525
https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.1244
https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-016-0297-z

Improve Arterial Elasticity with Walnuts

Improve Arterial Elasticity By Adding This Food to Your Diet

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

If you want to make your arteries healthier adding walnuts to your diet has been found to help.

Researchers with Yale University's Prevention Research Center asked two dozen men and women with type 2 diabetes to supplement their usual daily diets with 2 ounces of walnuts — about 30 shelled walnut halves — for eight weeks, then switch to a walnut-free diet (or vice versa). A test of blood flow through an artery in the forearm before and after each eight-week trial showed that walnuts improved the flexibility of the artery.

Studies have shown walnuts boost endothelial function.

A study in Barcelona conducted by Emilio Ros, MD, PhD, director of the Lipid Clinic at Hospital Clínico in Barcelona, Spain, took 24 randomized nonsmoking, middle-aged, healthy adults to one of two groups of 12. Each group was provided with two high-fat meals, eaten under supervision one week apart. The meals were identical, consisting of a salami-and-cheese sandwich on white bread and a small serving of full-fat yogurt. For one meal, the researchers added about five teaspoons (25 mL) of olive oil. For the other meal, they added 40 g of walnuts, or about eight shelled nuts.

Although both the olive oil and the walnuts lessened the sudden onset of inflammation and oxidation in the arteries it was discovered that walnuts helped preserve the elasticity and flexibility of the arteries.

It is also important to state that the inner lining of the arteries produces a substance called nitric oxide that is needed to keep the arteries flexible,” Dr. Ros said. “When we eat high-fat meals, the fat molecules temporarily disrupt the production of nitric oxide, preventing the arteries from increasing blood flow in response to physical activity.

One of the nutrients found in walnuts, he said, is arginine, an amino acid used by the body to produce nitric oxide.

How many ounces of walnuts should I eat a day?

According to Harvard Heart approximately one ounce of nuts daily can reduce your risk of heart disease. An ounce of walnuts is about a handful, or one-quarter cup. That amounts to between 12 and 14 halves or 30 grams of walnuts.

How to improve the nutrient benefits of walnuts

Walnuts should be soaked overnight (approximately 8-10 hours) because doing so makes them easier for the body to digest than eating them raw. The phytic acid found in nuts, which is reduced by soaking walnuts, contributes to increased absorption as well. The omega-3 fatty acids, known for their heart-healthy properties, are more readily absorbed when walnuts are soaked, boosting cardiovascular benefits.

Dr. Grisanti's Comments:

Arterial elasticity and flexibility are markers of optimal cardiovascular health. Although there are other factors that will help in improving arterial elasticity such as eating heart-healthy plant, based diet, eating wild fish (salmon), exercising for at least 30 to 60 minutes a day (150 minutes a week) and stopping smoking, something as simple as adding walnuts should be part of a total cardiovascular plan.

References:

https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000124477.91474.FF
https://www.pcrm.org/news/health-nutrition/walnuts-improve-artery-flexibility
https://www.clinicaladvisor.com/home/news/walnuts-help-keep-arteries-elastic/
https://www.acc.org/About-ACC/Press-Releases/2010/02/22/16/39/17-1
https://www.psu.edu/news/research/story/walnuts-may-help-lower-blood-pressure-those-risk-heart-disease/
https://www.nature.com/articles/ejcn2010233
https://www.health.harvard.edu/newsletter_article/walnuts-and-arteries

** Always consult with a physician or healthcare practitioner with significant integrative or functional medicine training before starting any of the above recommendations.

You can find a qualified and certified functional medicine practitioner by going to: www.FunctionalMedicineDoctors.com

Alcohol & Heart Disease

Current Research on Alcohol Consumption, Heart Disease and Cancer

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Alcohol consumption as it relates to the impact on heart disease and cancer has been a hot topic for many years.

Many people want to believe that the consumption of red wine is protective and for some even therapeutic for cardiovascular disease.

Unfortunately, strong peer-reviewed studies show the contrary.

In fact the evidence is so overwhelming that even a small amount of alcohol is outright dangerous!

Many misinformed people have thought the consumption of alcohol (red wine for some) increased HDL-C, had vasodilatory properties and anti-platelet activity (it thins your blood).

For some die hard recreational alcohol consumers the mention of red wine brings dreams of beneficial antioxidants like resveratrol and vitamin E.

Well, it turns out none of those things are true.

Many of the studies cited by proponents of limited alcohol consumption were subject to selection bias.

Unfortunately for lovers of recreational alcohol the current and most rigorous research show the total opposite to be true.

More and more powerful studies now show that even small amounts of alcohol can increase your risk for cardiovascular disease like coronary artery disease, heart failure, atrial fibrillation, hypertension, fatty liver, and aneurysms.

A meta-analysis published in 2018 in The Lancet (The Lancet publishes the best science from the best scientists worldwide, providing an unparalleled global reach and impact on health) looked at 599,912 drinkers with over 5.4 million person years of follow up. They found that all-cause mortality increased at 100g per week of alcohol.

Alcohol intake was also with a higher risk of stroke, coronary disease, heart failure, fatal hypertensive disease, and fatal aortic aneurysm. Those who reported consuming more than 100g/week and up to 350g/week had a shorter life expectancy by age 40, by 6 months and up to 5 years for those who consumed the most.

Now for those who claim they consume minimal amounts of alcohol the news is not good.

A study published in March of 2023 found that people who drank 25 to 44 g per day of alcohol had a small risk of all-cause mortality.

The risk became more significant for those who drank 45 to 64 g or more per day. There were larger risk for
mortality among female drinkers compared to female lifelong nondrinkers.

The World Heart Federation examined all the data and studies on CVD and alcohol consumption and determined that no amount was safe in terms of cardiovascular disease, cancer risk, and other causes of mortality.
Good summary in the below reference on alcohol by World Heart Federation alone is pure gold.

The World Heart Federation unites the diverse cardiovascular community to bring cardiovascular health to the forefront of the global health agenda – a global community of heart foundations, scientific societies and patient organizations, united in our mission to achieve heart health for everyone.

If you want to optimize your heart and brain health, avoid alcohol or keep it to the bare minimum.

Alcohol Consumption and Cancer

There is a strong scientific evidence that alcohol drinking can cause several types of cancer.

The US Department of Health and Human Services lists consumption of alcoholic beverages as a known human carcinogen.

The evidence shows that the more alcohol a person drinks the higher his or her risk of developing an alcohol-associated cancer. Even those who have no more than one drink per day have a modestly increased risk of some cancers. Based on data from 2009, an estimated 3.5% of cancer deaths in the United States (about 19,500 deaths) were alcohol related.

The following are the most researched between alcohol consumption and the development of the following types of cancer:

Head and neck cancer
Esophageal cancer
Liver cancer: Heavy alcohol consumption is associated with approximately 2-fold increased risks of two types of liver cancer (hepatocellular carcinoma and intrahepatic cholangiocarcinoma)
Breast cancer: Pooled data from 118 individual studies indicates that light drinkers have a slightly increased risk of breast cancer, compared with nondrinkers.
Colorectal cancer: Moderate to heavy alcohol consumption is associated with 1.2- to 1.5-fold increased risks of cancers of the colon and rectum compared with no alcohol consumption

Current Research on Alcohol Consumption, Heart Disease and Cancer

In addition to the above alcohol related cancers evidence is accumulating that alcohol consumption is associated with increased risks of melanoma and of prostate and pancreatic cancers.

A strong peer reviewed study that included data from more than 1,000 alcohol studies and data sources, as well as death and disability records from 195 countries and territories from 1990 to 2016, concluded that the optimal number of drinks to consume per day to minimize the overall risk to health is zero.

Dr. Grisanti's Comments:

For those who want to debate my article and stand firm of continuing to consume recreational alcohol clear and convincing evidence is strong that any potential benefits of alcohol consumption for reducing the risks of some cancers are likely outweighed by the harms of alcohol consumption.

References:

Cholesterol Truths-Mohammend Alo DO, FACC (Soon to be released)
https://www.thelancet.com/article/S0140-6736(18)30134-X/fulltext (copy and paste link)
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802963
//www.functionalmedicineuniversity.com/WorldHeartFederation.pdf
https://pubmed.ncbi.nlm.nih.gov/22910838/
https://pubmed.ncbi.nlm.nih.gov/26286216/
https://pubmed.ncbi.nlm.nih.gov/29112463/
https://pubmed.ncbi.nlm.nih.gov/21307158/
https://www.cancer.gov/about-cancer/causes-prevention/risk/alcohol/alcohol-fact-sheet
https://www.cancer.gov/news-events/cancer-currents-blog/2023/cancer-alcohol-link-public-awareness
https://www.cancer.org/cancer/risk-prevention/diet-physical-activity/alcohol-use-and-cancer.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590626/
https://www.who.int/europe/news/item/04-01-2023-no-level-of-alcohol-consumption-is-safe-for-our-health
https://www.mdanderson.org/cancerwise/does-alcohol-cause-cancer.h00-159383523.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705703/
https://www.thelancet.com/article/S1470-2045(21)00279-5/fulltext (copy and paste link)
https://pubmed.ncbi.nlm.nih.gov/27842506/
https://pubmed.ncbi.nlm.nih.gov/30146330/

** Always consult with a physician or healthcare practitioner with significant integrative or functional medicine training before starting any of the above recommendations.

You can find a qualified and certified functional medicine practitioner by going to: www.FunctionalMedicineDoctors.com

The Safety of Fish Oil Supplements:

It is Complicated and In the Details

The Simple Blood Test That Could Save Your Heart and Brain

Homocysteine

Additional Labs to Track for Cardiovascular Disease

Additional Lab Markers to Track and Monitor for Cardiovascular Disease

An Important Overlooked Cardiovascular Lab

An Important Overlooked Cardiovascular Lab Test Most Cardiologists Do Not Check (but Should)

Atrial Fibrillation and Dental Care

Atrial Fibrillation & Dental Care

Bacteria Linked to Atherosclerosis

Bacteria Linked to Atherosclerosis in the Most Unexpected Place

Benefits of Aged Garlic and Heart Health

Benefits of Aged Garlic & Heart Health

Congestive Heart Failure

Congestive Heart Failure--Traditional and Alternative Approach

Glyphosate (RoundUp) & Cardiovascular Disease

Glyphosate (RoundUp) & Cardiovascular Disease

Heart Failure & Galectin 3

Heart Failure & Galectin 3

How to Decrease Arterial Stiffness

How to Decrease Arterial Stiffness

Is Your Teen at Risk of Dying from Heart Failure?

Is Your Teenager At Risk of Dying From Heart Failure? What Every Parent MUST Know

Macadamia Nuts Enhance Heart Health

Macadamia Nuts-- The King of Tree Nuts

Nattokinase- Cardiovascular Benefits

Nattokinase- Cardiovascular Benefits

The Amazing Benefits of Olive Oil

The Amazing Benefits of Olive Oil (Be Aware of Fake Olive Oil)

What's Your Waist to Hip Ratio?

What's Your Waist to Hip Ratio? Your Health Depends on It

Improve Arterial Elasticity with Walnuts

Improve Arterial Elasticity By Adding This Food to Your Diet

Alcohol & Heart Disease

Current Research on Alcohol Consumption, Heart Disease and Cancer

This website uses cookies.